P63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
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ABSTRACT:
SUBMITTER: Keyes WM
PROVIDER: S-EPMC1482510 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Publications
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
Keyes William M WM Vogel Hannes H Koster Maranke I MI Guo Xuecui X Qi Yi Y Petherbridge Kristin M KM Roop Dennis R DR Bradley Allan A Mills Alea A AA
Proceedings of the National Academy of Sciences of the United States of America 20060519 22
Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/- mice in both WT and p53-compromised backgrounds. We found that p63+/- mice were not tumor prone and mice heterozygous for both p63 and p53 had fewer tumors than p53+/- mice. The rare tumors that developed in mice with comprom ...[more]
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