Ontology highlight
ABSTRACT:
SUBMITTER: Chen R
PROVIDER: S-EPMC1482610 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Chen Rong R Tilley Michael R MR Wei Hua H Zhou Fuwen F Zhou Fu-Ming FM Ching San S Quan Ning N Stephens Robert L RL Hill Erik R ER Nottoli Timothy T Han Dawn D DD Gu Howard H HH
Proceedings of the National Academy of Sciences of the United States of America 20060605 24
There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies support the dopamine (DA) hypothesis that the blockade of DAT and the subsequent increase in extracellular DA primarily mediate cocaine reward and reinforcement. Contrary to expectations, DAT knockout (DAT-KO) mice and SERT or NET knockout mice still self-administer cocaine and/or display conditioned place preferen ...[more]