Ontology highlight
ABSTRACT:
SUBMITTER: Rao PK
PROVIDER: S-EPMC1482645 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Rao Prakash K PK Kumar Roshan M RM Farkhondeh Mina M Baskerville Scott S Lodish Harvey F HF
Proceedings of the National Academy of Sciences of the United States of America 20060526 23
Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-1, miR-133 and miR-206, are robustly induced during the myoblast-myotube transition, both in primary human myoblasts and in the mouse mesenchymal C2C12 stem cell line. These microRNAs were not induced ...[more]