Ontology highlight
ABSTRACT:
SUBMITTER: Shi Q
PROVIDER: S-EPMC1483176 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20060701 7
Inhibitory immune response to exogenously infused factor VIII (FVIII) is a major complication in the treatment of hemophilia A. Generation of such inhibitors has the potential to disrupt gene therapy for hemophilia A. We explore what we believe to be a novel approach to overcome this shortcoming. Human B-domain-deleted FVIII (hBDDFVIII) was expressed under the control of the platelet-specific alphaIIb promoter in platelets of hemophilic (FVIIInull) mice to create 2bF8trans mice. The FVIII transg ...[more]