Experimental Pseudomonas aeruginosa keratitis in interleukin-10 gene knockout mice.
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ABSTRACT:
SUBMITTER: Cole N
PROVIDER: S-EPMC148849 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Publications
Experimental Pseudomonas aeruginosa keratitis in interleukin-10 gene knockout mice.
Cole Nerida N Krockenberger Mark M Stapleton Fiona F Khan Shamila S Hume Emma E Husband Alan J AJ Willcox Mark M
Infection and immunity 20030301 3
Pseudomonas aeruginosa keratitis is one of the most destructive diseases of the cornea. The host response to this infection is critical to the outcome. The cytokine interleukin-10 (IL-10) is thought to play an important role in modulating excessive inflammation and antimicrobial defenses. We have found that in IL-10(-/-) mice there is a significant decrease in bacterial load in corneas at 7 days postchallenge with P. aeruginosa. This decrease was accompanied by a reduction in neutrophil numbers ...[more]
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