Ontology highlight
ABSTRACT:
SUBMITTER: Connolly E
PROVIDER: S-EPMC1489005 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Connolly Eileen E Braunstein Steve S Formenti Silvia S Schneider Robert J RJ
Molecular and cellular biology 20060501 10
Hypoxia is a state of low oxygen availability that limits tumor growth. The mechanism of protein synthesis inhibition by hypoxia and its circumvention by transformation are not well understood. Hypoxic breast epithelial cells are shown to downregulate protein synthesis by inhibition of the kinase mTOR, which suppresses mRNA translation through a novel mechanism mitigated in transformed cells: disruption of proteasome-targeted degradation of eukaryotic elongation factor 2 (eEF2) kinase and activa ...[more]