Ontology highlight
ABSTRACT:
SUBMITTER: Lis ET
PROVIDER: S-EPMC1489103 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Lis Ewa T ET Romesberg Floyd E FE
Molecular and cellular biology 20060601 11
The cellular response to DNA damage requires not only direct repair of the damage but also changes in the DNA replication machinery, chromatin, and transcription that facilitate survival. Here, we describe Saccharomyces cerevisiae Doa1, which helps to control the damage response by channeling ubiquitin from the proteosomal degradation pathway into pathways that mediate altered DNA replication and chromatin modification. DOA1 interacts with genes involved in PCNA ubiquitination, including RAD6, R ...[more]