Characterization of a novel porin involved in systemic Yersinia enterocolitica infection.
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ABSTRACT:
SUBMITTER: Mildiner-Earley S
PROVIDER: S-EPMC1489722 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
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Characterization of a novel porin involved in systemic Yersinia enterocolitica infection.
Mildiner-Earley Shirly S Miller Virginia L VL
Infection and immunity 20060701 7
Yersinia enterocolitica is an enteric pathogen capable of causing systemic disease in a murine model. We have identified a novel protein, systemic factor protein A (SfpA), conserved in other pathogenic bacteria that is involved in systemic disease. Analysis of bacterial colonization revealed that a DeltasfpA strain is defective in mesenteric lymph node colonization. Bioinformatics and functional studies suggest that SfpA is a porin. ...[more]
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2008-04-17 | GSE11189 | GEO