A new sulfonamide resistance gene (sul3) in Escherichia coli is widespread in the pig population of Switzerland.
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ABSTRACT:
SUBMITTER: Perreten V
PROVIDER: S-EPMC149312 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
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A new sulfonamide resistance gene (sul3) in Escherichia coli is widespread in the pig population of Switzerland.
Perreten Vincent V Boerlin Patrick P
Antimicrobial agents and chemotherapy 20030301 3
A new gene, sul3, which specifies a 263-amino-acid protein similar to a dihydropteroate synthase encoded by the 54-kb conjugative plasmid pVP440 from Escherichia coli was characterized. Expression of the cloned sul3 gene conferred resistance to sulfamethoxazole on E. coli. Two copies of the insertion element IS15Delta/26 flanked the region containing sul3. The sul3 gene was detected in one-third of the sulfonamide-resistant pathogenic E. coli isolates from pigs in Switzerland. ...[more]
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