Ontology highlight
ABSTRACT:
SUBMITTER: Trozzi C
PROVIDER: S-EPMC149541 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Trozzi Caterina C Bartholomew Linda L Ceccacci Alessandra A Biasiol Gabriella G Pacini Laura L Altamura Sergio S Narjes Frank F Muraglia Ester E Paonessa Giacomo G Koch Uwe U De Francesco Raffaele R Steinkuhler Christian C Migliaccio Giovanni G
Journal of virology 20030301 6
The hepatitis C virus (HCV) serine protease is necessary for viral replication and represents a valid target for developing new therapies for HCV infection. Potent and selective inhibitors of this enzyme have been identified and shown to inhibit HCV replication in tissue culture. The optimization of these inhibitors for clinical development would greatly benefit from in vitro systems for the identification and the study of resistant variants. We report the use HCV subgenomic replicons to isolate ...[more]