Ontology highlight
ABSTRACT:
SUBMITTER: Vester B
PROVIDER: S-EPMC1501032 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Vester Birte B Hansen Lykke H LH Lundberg Lars Bo LB Babu B Ravindra BR Sørensen Mads D MD Wengel Jesper J Douthwaite Stephen S
BMC molecular biology 20060605
<h4>Background</h4>DNAzymes cleave at predetermined sequences within RNA. A prerequisite for cleavage is that the DNAzyme can gain access to its target, and thus the DNAzyme must be capable of unfolding higher-order structures that are present in the RNA substrate. However, in many cases the RNA target sequence is hidden in a region that is too tightly structured to be accessed under physiological conditions by DNAzymes.<h4>Results</h4>We investigated how incorporation of LNA (locked nucleic aci ...[more]