Ontology highlight
ABSTRACT:
SUBMITTER: Hatano M
PROVIDER: S-EPMC1501889 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Hatano Manabu M Eguchi Junichi J Tatsumi Tomohide T Kuwashima Naruo N Dusak Jill E JE Kinch Michel S MS Pollack Ian F IF Hamilton Ronald L RL Storkus Walter J WJ Okada Hideho H
Neoplasia (New York, N.Y.) 20050801 8
EphA2 is a receptor tyrosine kinase and is frequently overexpressed in a wide array of advanced cancers. We demonstrate in the current study that the EphA2 protein is restrictedly expressed in primary glioblastoma multiforme and anaplastic astrocytoma tissues in comparison to normal brain tissues. To evaluate the possibility of targeting EphA2 in glioma vaccine strategies, we stimulated human leukocyte antigen (HLA) A2+ peripheral blood mononuclear cells (PBMCs) obtained from healthy donors and ...[more]