Ontology highlight
ABSTRACT:
SUBMITTER: Schwer B
PROVIDER: S-EPMC1502439 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Schwer Bjoern B Bunkenborg Jakob J Verdin Regis O RO Andersen Jens S JS Verdin Eric E
Proceedings of the National Academy of Sciences of the United States of America 20060620 27
We report that human acetyl-CoA synthetase 2 (AceCS2) is a mitochondrial matrix protein. AceCS2 is reversibly acetylated at Lys-642 in the active site of the enzyme. The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys-642 both in vitro and in vivo. Deacetylation of AceCS2 by SIRT3 activates the acetyl-CoA synthetase activity of AceCS2. This report identifies the first acetylated substrate protein of SIRT3. Our findings show that a mammalian sirtuin directly controls the ac ...[more]