Ontology highlight
ABSTRACT:
SUBMITTER: Truksa J
PROVIDER: S-EPMC1502450 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Truksa Jaroslav J Peng Hongfan H Lee Pauline P Beutler Ernest E
Proceedings of the National Academy of Sciences of the United States of America 20060626 27
Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4. We investigate the role of Hfe, Tfr2 (transferrin receptor 2), and IL-6 in BMP2-, BMP4-, and BMP9-stimulated up-regulation of murine hepcidin, because these molecules, like Hjv, are known to be involved in hepcidin signaling. We show that the BMP signaling pathway acts ind ...[more]