Breakup of a homeobox cluster after genome duplication in teleosts.
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ABSTRACT:
SUBMITTER: Mulley JF
PROVIDER: S-EPMC1502464 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Publications
Breakup of a homeobox cluster after genome duplication in teleosts.
Mulley John F JF Chiu Chi-Hua CH Holland Peter W H PWH
Proceedings of the National Academy of Sciences of the United States of America 20060626 27
Several families of homeobox genes are arranged in genomic clusters in metazoan genomes, including the Hox, ParaHox, NK, Rhox, and Iroquois gene clusters. The selective pressures responsible for maintenance of these gene clusters are poorly understood. The ParaHox gene cluster is evolutionarily conserved between amphioxus and human but is fragmented in teleost fishes. We show that two basal ray-finned fish, Polypterus and Amia, each possess an intact ParaHox cluster; this implies that the select ...[more]
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