Ontology highlight
ABSTRACT:
SUBMITTER: Sakane A
PROVIDER: S-EPMC1502500 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Sakane Ayuko A Manabe Shinji S Ishizaki Hiroyoshi H Tanaka-Okamoto Miki M Kiyokage Emi E Toida Kazunori K Yoshida Takayuki T Miyoshi Jun J Kamiya Haruyuki H Takai Yoshimi Y Sasaki Takuya T
Proceedings of the National Academy of Sciences of the United States of America 20060616 26
Rab3A small G protein is a member of the Rab family and is most abundant in the brain, where it is localized on synaptic vesicles. Evidence is accumulating that Rab3A plays a key role in neurotransmitter release and synaptic plasticity. Rab3A cycles between the GDP-bound inactive and GTP-bound active forms, and this change in activity is associated with the trafficking cycle of synaptic vesicles at nerve terminals. Rab3 GTPase-activating protein (GAP) stimulates the GTPase activity of Rab3A and ...[more]