Ontology highlight
ABSTRACT:
SUBMITTER: Moskalenko SE
PROVIDER: S-EPMC150568 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Moskalenko Svetlana E SE Chabelskaya Svetlana V SV Inge-Vechtomov Sergei G SG Philippe Michel M Zhouravleva Galina A GA
BMC molecular biology 20030210
<h4>Background</h4>Termination of protein synthesis in eukaryotes involves at least two polypeptide release factors (eRFs) - eRF1 and eRF3. The highly conserved translation termination factor eRF1 in Saccharomyces cerevisiae is encoded by the essential gene SUP45.<h4>Results</h4>We have isolated five sup45-n (n from nonsense) mutations that cause nonsense substitutions in the following amino acid positions of eRF1: Y53 --> UAA, E266 --> UAA, L283 --> UAA, L317 --> UGA, E385 --> UAA. We found tha ...[more]