Ontology highlight
ABSTRACT:
SUBMITTER: Colgin LM
PROVIDER: S-EPMC1507985 | biostudies-literature | 2000 Sep-Oct
REPOSITORIES: biostudies-literature
Colgin L M LM Wilkinson C C Englezou A A Kilian A A Robinson M O MO Reddel R R RR
Neoplasia (New York, N.Y.) 20000901 5
The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes. Maintenance of telomeres by telomerase or another mechanism is required for cell immortalization, and loss of telomeric DNA has been proposed as a trigger for cellular senescence. Available evidence suggests that regulation of telomerase activity primarily depends on transcriptional control of hTERT. However, several human tissues as well as s ...[more]