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RNA interference directs innate immunity against viruses in adult Drosophila.

ABSTRACT: Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

SUBMITTER: Wang XH

PROVIDER: S-EPMC1509097 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature

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RNA interference directs innate immunity against viruses in adult Drosophila.

Wang Xiao-Hong XH Aliyari Roghiyh R Li Wan-Xiang WX Li Hong-Wei HW Kim Kevin K Carthew Richard R Atkinson Peter P Ding Shou-Wei SW

Science (New York, N.Y.) 20060323 5772

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Arg ...[more]

PMID: 16556799

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| S-EPMC2522277 | biostudies-literature

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