Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level.

ABSTRACT:

Background

Genome projects have provided a vast amount of sequence information. Sequence comparison between species helps to establish functional catalogues within organisms and to study how they are maintained and modified across phylogenetic groups during evolution. Microarray studies allow us to determine groups of genes with similar temporal regulation and perhaps also common regulatory upstream regions for binding of transcription factors. The integration of sequence and expression data is expected to refine our current annotations and provide some insight into the evolution of gene regulation across organisms.

Results

We have investigated how well the protein subcellular localization and functional categories established from clustering of orthologous genes agree with

SUBMITTER: Jimenez JL 

PROVIDER: S-EPMC151285 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature