Ontology highlight
ABSTRACT:
SUBMITTER: Achard P
PROVIDER: S-EPMC1513272 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Achard Pablo P De Schutter Erik E
PLoS computational biology 20060701 7
The electrical activity of a neuron is strongly dependent on the ionic channels present in its membrane. Modifying the maximal conductances from these channels can have a dramatic impact on neuron behavior. But the effect of such modifications can also be cancelled out by compensatory mechanisms among different channels. We used an evolution strategy with a fitness function based on phase-plane analysis to obtain 20 very different computational models of the cerebellar Purkinje cell. All these m ...[more]