Ontology highlight
ABSTRACT:
SUBMITTER: Klein U
PROVIDER: S-EPMC151393 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Klein Ulf U Tu Yuhai Y Stolovitzky Gustavo A GA Keller Jeffrey L JL Haddad Joseph J Miljkovic Vladan V Cattoretti Giorgio G Califano Andrea A Dalla-Favera Riccardo R
Proceedings of the National Academy of Sciences of the United States of America 20030225 5
The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that occur in B cells during GC transit (naive B cells --> centroblasts --> centrocytes --> memory B cells) by gene expression profiling. Naive B cells, characterized by the expression of cell cycle-inhibitory and antiapoptotic genes, become centroblasts by inducing an atypical proliferation program lacking c-Myc expression, sw ...[more]