Molecular characterization of the prototrophic Salmonella mutants defective for intraepithelial replication.
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ABSTRACT:
SUBMITTER: Suvarnapunya AE
PROVIDER: S-EPMC152099 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Publications
Molecular characterization of the prototrophic Salmonella mutants defective for intraepithelial replication.
Suvarnapunya Akamol E AE Zurawski Daniel V DV Guy Rebecca L RL Stein Murry A MA
Infection and immunity 20030401 4
Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmonella pathogenicity island 2 function underlies the intracellular replication defect of 3-11 and 17-21. ...[more]
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