Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.
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ABSTRACT:
SUBMITTER: Gradi A
PROVIDER: S-EPMC152112 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
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Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.
Gradi Alessandra A Svitkin Yuri V YV Sommergruber Wolfgang W Imataka Hiroaki H Morino Shigenobu S Skern Tim T Sonenberg Nahum N
Journal of virology 20030401 8
Several picornaviruses shut down host cellular protein synthesis by proteolytic cleavage of the eukaryotic initiation factor (eIF) 4GI and eIF4GII isoforms. Viral RNA translation is maintained by a cap-independent mechanism. Here, we identify the human rhinovirus 2 2A(pro) cleavage site in eIF4GII in vitro as PLLNV(699)*GSR; this sequence lies seven amino acids C-terminal to the cleavage site previously identified in eIF4GI (LSTR681*GPP). ...[more]
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