Ontology highlight
ABSTRACT:
SUBMITTER: McConkey BJ
PROVIDER: S-EPMC152272 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
McConkey Brendan J BJ Sobolev Vladimir V Edelman Marvin M
Proceedings of the National Academy of Sciences of the United States of America 20030311 6
We introduce a method for discriminating correctly folded proteins from well designed decoy structures using atom-atom and atom-solvent contact surfaces. The measure used to quantify contact surfaces integrates the solvent accessible surface and interatomic contacts into one quantity, allowing solvent to be treated as an atom contact. A scoring function was derived from statistical contact preferences within known protein structures and validated by using established protein decoy sets, includin ...[more]