Ontology highlight
ABSTRACT:
SUBMITTER: Gilad Y
PROVIDER: S-EPMC152291 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Gilad Yoav Y Man Orna O Pääbo Svante S Lancet Doron D
Proceedings of the National Academy of Sciences of the United States of America 20030228 6
Olfactory receptor (OR) genes constitute the basis for the sense of smell and are encoded by the largest mammalian gene superfamily of >1,000 genes. In humans, >60% of these are pseudogenes. In contrast, the mouse OR repertoire, although of roughly equal size, contains only approximately 20% pseudogenes. We asked whether the high fraction of nonfunctional OR genes is specific to humans or is a common feature of all primates. To this end, we have compared the sequences of 50 human OR coding regio ...[more]