Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.
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ABSTRACT:
SUBMITTER: Wiltshire T
PROVIDER: S-EPMC152301 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Publications
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.
Wiltshire Tim T Pletcher Mathew T MT Batalov Serge S Barnes S Whitney SW Tarantino Lisa M LM Cooke Michael P MP Wu Hua H Smylie Kevin K Santrosyan Andrey A Copeland Neal G NG Jenkins Nancy A NA Kalush Francis F Mural Richard J RJ Glynne Richard J RJ Kay Steve A SA Adams Mark D MD Fletcher Colin F CF
Proceedings of the National Academy of Sciences of the United States of America 20030228 6
The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high ...[more]
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