Ontology highlight
ABSTRACT:
SUBMITTER: Schmollinger JC
PROVIDER: S-EPMC152304 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Schmollinger Jan C JC Vonderheide Robert H RH Hoar Kara M KM Maecker Britta B Schultze Joachim L JL Hodi F Stephen FS Soiffer Robert J RJ Jung Ken K Kuroda Marcelo J MJ Letvin Norman L NL Greenfield Edward A EA Mihm Martin M Kutok Jeffery L JL Dranoff Glenn G
Proceedings of the National Academy of Sciences of the United States of America 20030307 6
The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor generates potent, specific, and long-lasting antitumor immunity through improved tumor antigen presentation by dendritic cells and macrophages. A phase I clinical trial of this immunization strategy in patients with disseminated melanoma revealed the consistent induction in distant met ...[more]