Ontology highlight
ABSTRACT:
SUBMITTER: Zaitseva J
PROVIDER: S-EPMC1523178 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
The EMBO journal 20060706 14
The ATP-binding cassette (ABC)-transporter haemolysin (Hly)B, a central element of a Type I secretion machinery, acts in concert with two additional proteins in Escherichia coli to translocate the toxin HlyA directly from the cytoplasm to the exterior. The basic set of crystal structures necessary to describe the catalytic cycle of the isolated HlyB-NBD (nucleotide-binding domain) has now been completed. This allowed a detailed analysis with respect to hinge regions, functionally important key r ...[more]