Ontology highlight
ABSTRACT:
SUBMITTER: Giallourakis C
PROVIDER: S-EPMC1524865 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Giallourakis Cosmas C Cao Zhifang Z Green Todd T Wachtel Heather H Xie Xiaohui X Lopez-Illasaca Marco M Daly Mark M Rioux John J Xavier Ramnik R
Genome research 20060706 8
PDZ domain-containing proteins and their interaction partners are mutated in numerous human diseases and function in complexes regulating epithelial polarity, ion channels, cochlear hair cell development, vesicular sorting, and neuronal synaptic communication. Among several properties of a collection of documented PDZ domain-ligand interactions, we discovered embedded in a large-scale expression data set the existence of a significant level of co-regulation between PDZ domain-encoding genes and ...[more]