Ontology highlight
ABSTRACT:
SUBMITTER: Qi W
PROVIDER: S-EPMC1525235 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Qi Wei W Tang Zhanyun Z Yu Hongtao H
Molecular biology of the cell 20060607 8
Polo-like kinase 1 (Plk1) is required for the generation of the tension-sensing 3F3/2 kinetochore epitope and facilitates kinetochore localization of Mad2 and other spindle checkpoint proteins. Here, we investigate the mechanism by which Plk1 itself is recruited to kinetochores. We show that Plk1 binds to budding uninhibited by benzimidazole 1 (Bub1) in mitotic human cells. The Plk1-Bub1 interaction requires the polo-box domain (PBD) of Plk1 and is enhanced by cyclin-dependent kinase 1 (Cdk1)-me ...[more]