Ontology highlight
ABSTRACT:
SUBMITTER: Konecna A
PROVIDER: S-EPMC1525238 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Konecna Anetta A Frischknecht Renato R Kinter Jochen J Ludwig Alexander A Steuble Martin M Meskenaite Virginia V Indermühle Martin M Engel Marianne M Cen Chuan C Mateos José-Maria JM Streit Peter P Sonderegger Peter P
Molecular biology of the cell 20060607 8
We identified a direct interaction between the neuronal transmembrane protein calsyntenin-1 and the light chain of Kinesin-1 (KLC1). GST pulldowns demonstrated that two highly conserved segments in the cytoplasmic domain of calsyntenin-1 mediate binding to the tetratricopeptide repeats of KLC1. A complex containing calsyntenin-1 and the Kinesin-1 motor was isolated from developing mouse brain and immunoelectron microscopy located calsyntenin-1 in association with tubulovesicular organelles in ax ...[more]