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Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review.


ABSTRACT: OBJECTIVES:To ascertain the prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease and its association with the disease. DESIGN:Systematic review of studies reporting the prevalence of H pylori in patients with and without gastro-oesophageal reflux disease. DATA SOURCES:Four electronic databases, searched to November 2001, experts, pharmaceutical companies, and journals. MAIN OUTCOME MEASURE:Odds ratio for prevalence of H pylori in patients with gastro-oesophageal reflux disease. RESULTS:20 studies were included. The pooled estimate of the odds ratio for prevalence of H pylori was 0.60 (95% confidence interval 0.47 to 0.78), indicating a lower prevalence in patients with gastro-oesophageal reflux disease. Substantial heterogeneity was observed between studies. Location seemed to be an important factor, with a much lower prevalence of H pylori in patients with gastro-oesophageal reflux disease in studies from the Far East, despite a higher overall prevalence of infection than western Europe and North America. Year of study was not a source of heterogeneity. CONCLUSION:The prevalence of H pylori infection was significantly lower in patients with than without gastro-oesophageal reflux, with geographical location being a strong contributor to the heterogeneity between studies. Patients from the Far East with reflux disease had a lower prevalence of H pylori infection than patients from western Europe and North America, despite a higher prevalence in the general population.

SUBMITTER: Raghunath A 

PROVIDER: S-EPMC152634 | biostudies-literature | 2003 Apr

REPOSITORIES: biostudies-literature

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Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review.

Raghunath Anan A   Hungin A Pali S AP   Wooff David D   Childs Susan S  

BMJ (Clinical research ed.) 20030401 7392


<h4>Objectives</h4>To ascertain the prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease and its association with the disease.<h4>Design</h4>Systematic review of studies reporting the prevalence of H pylori in patients with and without gastro-oesophageal reflux disease.<h4>Data sources</h4>Four electronic databases, searched to November 2001, experts, pharmaceutical companies, and journals.<h4>Main outcome measure</h4>Odds ratio for prevalence of H pylori in patie  ...[more]

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