Ontology highlight
ABSTRACT:
SUBMITTER: Armbruster BN
PROVIDER: S-EPMC153184 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Armbruster Blaine N BN Etheridge Katherine T KT Broccoli Dominique D Counter Christopher M CM
Molecular and cellular biology 20030501 9
Telomerase, the enzyme that elongates telomeres, is essential to maintain telomere length and to immortalize most cancer cells. However, little is known about the regulation of this enzyme in higher eukaryotes. We previously described a domain in the hTERT telomerase catalytic subunit that is essential for telomere elongation and cell immortalization in vivo but dispensable for catalytic activity in vitro. Here, we show that fusions of hTERT containing different mutations in this domain to the t ...[more]