Ontology highlight
ABSTRACT:
SUBMITTER: Bayliss PE
PROVIDER: S-EPMC1534118 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Bayliss Peter E PE Bellavance Kimberly L KL Whitehead Geoffrey G GG Abrams Joshua M JM Aegerter Sandrine S Robbins Heather S HS Cowan Douglas B DB Keating Mark T MT O'Reilly Terence T Wood Jeanette M JM Roberts Thomas M TM Chan Joanne J
Nature chemical biology 20060326 5
We examined the role of angiogenesis and the need for receptor signaling using chemical inhibition of the vascular endothelial growth factor receptor in the adult zebrafish tail fin. Using a small-molecule inhibitor, we were able to exert precise control over blood vessel regeneration. An angiogenic limit to tissue regeneration was determined, as avascular tissue containing skin, pigment, neuronal axons and bone precursors could regenerate up to about 1 mm. This indicates that tissues can regene ...[more]