Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC15347 | biostudies-literature | 1999 Feb
REPOSITORIES: biostudies-literature
Li Y Y Kang J J Friedman J J Tarassishin L L Ye J J Kovalenko A A Wallach D D Horwitz M S MS
Proceedings of the National Academy of Sciences of the United States of America 19990201 3
FIP-3 (14.7K interacting protein) was discovered during a search for cell proteins that could interact with an adenovirus protein (Ad E3-14.7K) that had been shown to prevent tumor necrosis factor (TNF)-alpha-induced cytolysis. FIP-3, which contains leucine zippers and a zinc finger domain, inhibits both basal and induced transcriptional activity of NF-kappaB and causes a late-appearing apoptosis with unique morphologic manifestations. Ad E3-14.7K can partially reverse apoptotic death induced by ...[more]