Ontology highlight
ABSTRACT:
SUBMITTER: Haggarty SJ
PROVIDER: S-EPMC153564 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Haggarty Stephen J SJ Koeller Kathryn M KM Wong Jason C JC Grozinger Christina M CM Schreiber Stuart L SL
Proceedings of the National Academy of Sciences of the United States of America 20030403 8
Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone deacetylase inhibitors are currently in clinical trials for the treatment of cancer. These and other inhibitors also affect microtubule acetylation. A multidimensional, chemical genetic screen of 7,392 small molecules was used to discover "tubacin," which inhibits alpha-tubulin deacetylation in mammalian cells. Tubacin does not affect the level of ...[more]