Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.
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ABSTRACT:
SUBMITTER: Strain MC
PROVIDER: S-EPMC153639 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
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Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.
Strain M C MC Günthard H F HF Havlir D V DV Ignacio C C CC Smith D M DM Leigh-Brown A J AJ Macaranas T R TR Lam R Y RY Daly O A OA Fischer M M Opravil M M Levine H H Bacheler L L Spina C A CA Richman D D DD Wong J K JK
Proceedings of the National Academy of Sciences of the United States of America 20030408 8
Viral replication and latently infected cellular reservoirs persist in HIV-infected patients achieving undetectable plasma virus levels with potent antiretroviral therapy. We exploited a predictable drug resistance mutation in the HIV reverse transcriptase to label and track cells infected during defined intervals of treatment and to identify cells replenished by ongoing replication. Decay rates of subsets of latently HIV-infected cells paradoxically decreased with time since establishment, refl ...[more]
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