Ontology highlight
ABSTRACT:
SUBMITTER: Malacombe M
PROVIDER: S-EPMC1538555 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Malacombe Magali M Ceridono Mara M Calco Valérie V Chasserot-Golaz Sylvette S McPherson Peter S PS Bader Marie-France MF Gasman Stéphane S
The EMBO journal 20060727 15
Rho GTPases are key regulators of the actin cytoskeleton in membrane trafficking events. We previously reported that Cdc42 facilitates exocytosis in neuroendocrine cells by stimulating actin assembly at docking sites for secretory granules. These findings raise the question of the mechanism activating Cdc42 in exocytosis. The neuronal guanine nucleotide exchange factor, intersectin-1L, which specifically activates Cdc42 and is at an interface between membrane trafficking and actin dynamics, appe ...[more]