Ontology highlight
ABSTRACT:
SUBMITTER: Weems JJ
PROVIDER: S-EPMC1538656 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Weems J John JJ Steinberg James P JP Filler Scott S Baddley John W JW Corey G Ralph GR Sampathkumar Priya P Winston Lisa L John Joseph F JF Kubin Christine J CJ Talwani Rohit R Moore Thomas T Patti Joseph M JM Hetherington Seth S Texter Michele M Wenzel Eric E Kelley Violet A VA Fowler Vance G VG
Antimicrobial agents and chemotherapy 20060801 8
Tefibazumab (Aurexis), a humanized monoclonal antibody that binds to the surface-expressed adhesion protein clumping factor A, is under development as adjunctive therapy for serious Staphylococcus aureus infections. Sixty patients with documented S. aureus bacteremia (SAB) were randomized and received either tefibazumab at 20 mg/kg of body weight as a single infusion or a placebo in addition to an antibiotic(s). The primary objective of the study was determining safety and pharmacokinetics. An a ...[more]