Ontology highlight
ABSTRACT:
SUBMITTER: Tynan-Connolly BM
PROVIDER: S-EPMC1538816 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20060701 Web Server issue
The pK(a) values in proteins govern the pH-dependence of protein stability and enzymatic activity. A large number of mutagenesis experiments have been carried out in the last three decades to re-engineer the pH-activity and pH-stability profile of enzymes and proteins. We have developed the pKD webserver (http://polymerase.ucd.ie/pKa_Design), which predicts sets of point mutations that will change the pK(a) values of a set of target residues in a given direction, thus allowing for targeted re-de ...[more]