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SABBAC: online Structural Alphabet-based protein BackBone reconstruction from Alpha-Carbon trace.


ABSTRACT: SABBAC is an on-line service devoted to protein backbone reconstruction from alpha-carbon trace. It is based on the assembly of fragments taken from a library of reduced size, selected from the encoding of the protein trace in a hidden Markov model-derived structural alphabet. The assembly of the fragments is achieved by a greedy algorithm, using an energy-based scoring. Alpha-carbon coordinates remain unaffected. SABBAC simply positions the missing backbone atoms, no further refinement is performed. From our tests, SABBAC performs equal or better than other similar on-line approach and is robust to deviations on the alpha-carbon coordinates. It can be accessed at http://bioserv.rpbs.jussieu.fr/SABBAC.html.

SUBMITTER: Maupetit J 

PROVIDER: S-EPMC1538914 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

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SABBAC: online Structural Alphabet-based protein BackBone reconstruction from Alpha-Carbon trace.

Maupetit Julien J   Gautier R R   Tufféry Pierre P  

Nucleic acids research 20060701 Web Server issue


SABBAC is an on-line service devoted to protein backbone reconstruction from alpha-carbon trace. It is based on the assembly of fragments taken from a library of reduced size, selected from the encoding of the protein trace in a hidden Markov model-derived structural alphabet. The assembly of the fragments is achieved by a greedy algorithm, using an energy-based scoring. Alpha-carbon coordinates remain unaffected. SABBAC simply positions the missing backbone atoms, no further refinement is perfo  ...[more]

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