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Study of thioglycosylation in ionic liquids.

ABSTRACT: A novel, green chemistry, glycosylation strategy was developed based upon the use of ionic liquids. Research studies demonstrated that thiomethyl glycosides could readily be activated with methyl trifluoromethane sulfonate, using 1-butyl-3-methylimidazolium tetrafluoroborate as a solvent. This green chemistry glycosylation strategy provided disaccharides with typical yields averaging 75%. The ionic liquid solvent could be readily reused for five sequential glycosylation reactions with no impact on product yield.

SUBMITTER: Zhang J

PROVIDER: S-EPMC1540430 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Study of thioglycosylation in ionic liquids.

Zhang Jianguo J Ragauskas Arthur A

Beilstein journal of organic chemistry 20060627

A novel, green chemistry, glycosylation strategy was developed based upon the use of ionic liquids. Research studies demonstrated that thiomethyl glycosides could readily be activated with methyl trifluoromethane sulfonate, using 1-butyl-3-methylimidazolium tetrafluoroborate as a solvent. This green chemistry glycosylation strategy provided disaccharides with typical yields averaging 75%. The ionic liquid solvent could be readily reused for five sequential glycosylation reactions with no impact ...[more]

PMID: 16803635

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