Ontology highlight
ABSTRACT:
SUBMITTER: Fratti RA
PROVIDER: S-EPMC154363 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Fratti Rutilio A RA Chua Jennifer J Vergne Isabelle I Deretic Vojo V
Proceedings of the National Academy of Sciences of the United States of America 20030417 9
The tubercle bacillus parasitizes macrophages by inhibiting phagosome maturation into the phagolysosome. This phenomenon underlies the tuberculosis pandemic involving 2 billion people. We report here how Mycobacterium tuberculosis causes phagosome maturation arrest. A glycosylated M. tuberculosis phosphatidylinositol [mannose-capped lipoarabinomannan (ManLAM)] interfered with the phagosomal acquisition of the lysosomal cargo and syntaxin 6 from the trans-Golgi network. ManLAM specifically inhibi ...[more]