Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance.
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ABSTRACT:
SUBMITTER: Limansky AS
PROVIDER: S-EPMC154632 | biostudies-literature | 2002 Dec
REPOSITORIES: biostudies-literature
Publications
Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance.
Limansky Adriana S AS Mussi María Alejandra MA Viale Alejandro M AM
Journal of clinical microbiology 20021201 12
We analyzed the possible causes of imipenem (IPM) resistance in multidrug-resistant isolates of Acinetobacter baumannii. Comparison of the outer membrane protein (OMP) profiles of two genomically related strains (Ab288 [IPM sensitive] and Ab242 [IPM resistant]) indicated the conspicuous loss of a 29-kDa polypeptide in the Ab242 strain. No carbapenemase activity was detected in any of these strains. The treatment of Ab288 with sodium salicylate resulted in IPM resistance and the loss of the 29-kD ...[more]
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