Ontology highlight
ABSTRACT:
SUBMITTER: Mendez E
PROVIDER: S-EPMC155114 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Méndez Ernesto E Fernández-Luna Teresa T López Susana S Méndez-Toss Martha M Arias Carlos F CF
Journal of virology 20020801 16
Astroviruses require the proteolytic cleavage of the capsid protein to infect the host cell. Here we describe the processing pathway of the primary translation product of the structural polyprotein (ORF2) encoded by a human astrovirus serotype 8 (strain Yuc8). The primary translation product of ORF2 is of approximately 90 kDa, which is subsequently cleaved to yield a 70-kDa protein (VP70) which is assembled into the viral particles. Limited trypsin treatment of purified particles containing VP70 ...[more]