Ontology highlight
ABSTRACT:
SUBMITTER: Korsisaari N
PROVIDER: S-EPMC155213 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Korsisaari Nina N Rossi Derrick J DJ Luukko Keijo K Huebner Kay K Henkemeyer Mark M Mäkelä Tomi P TP
Molecular and cellular biology 20030601 11
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study the function of Hint and to explore its possible role in modulating Cdk7 activity in vivo, we have characterized the expression pattern of murine Hint and generated Hint-deficient (Hint(-/-)) mice. Hint was widely expressed during mouse development, with pronounced expression in several neuronal gangli ...[more]