Ontology highlight
ABSTRACT:
SUBMITTER: Weinmann AS
PROVIDER: S-EPMC155318 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
Weinmann Amy S AS Yan Pearlly S PS Oberley Matthew J MJ Huang Tim Hui-Ming TH Farnham Peggy J PJ
Genes & development 20020101 2
Previously, identification of promoters regulated by mammalian transcription factors has relied upon overexpression studies. Here we present the identification of a large set of promoters that are bound by E2F in physiological conditions. Probing a human CpG microarray with chromatin immunoprecipitated using an antibody to E2F4, we have identified 68 unique target loci; 15% are bidirectional promoters and 25% recruit E2F via a mechanism distinct from the defined consensus site. Interestingly, al ...[more]