Ontology highlight
ABSTRACT:
SUBMITTER: Boriskin YS
PROVIDER: S-EPMC1559594 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Boriskin Yury S YS Pécheur Eve-Isabelle EI Polyak Stephen J SJ
Virology journal 20060719
Arbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its effect on hepatitis C virus (HCV) infection and replication in cell culture. Long-term ARB treatment of Huh7 cells chronically replicating a genomic length genotype 1b replicon resulted in sustained reduction of viral RNA and protein expression, and eventually cured HCV infected ...[more]