Unknown

Dataset Information

0

Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection.


ABSTRACT: Arbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its effect on hepatitis C virus (HCV) infection and replication in cell culture. Long-term ARB treatment of Huh7 cells chronically replicating a genomic length genotype 1b replicon resulted in sustained reduction of viral RNA and protein expression, and eventually cured HCV infected cells. Pre-treatment of human hepatoma Huh7.5.1 cells with 15 microM ARB for 24 to 48 hours inhibited acute infection with JFH-1 virus by up to 1000-fold. The inhibitory effect of ARB on HCV was not due to generalized cytotoxicity, nor to augmentation of IFN antiviral signaling pathways, but involved impaired virus-mediated membrane fusion. ARB's affinity for membranes may inhibit several aspects of the HCV lifecycle that are membrane-dependent.

SUBMITTER: Boriskin YS 

PROVIDER: S-EPMC1559594 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection.

Boriskin Yury S YS   Pécheur Eve-Isabelle EI   Polyak Stephen J SJ  

Virology journal 20060719


Arbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its effect on hepatitis C virus (HCV) infection and replication in cell culture. Long-term ARB treatment of Huh7 cells chronically replicating a genomic length genotype 1b replicon resulted in sustained reduction of viral RNA and protein expression, and eventually cured HCV infected  ...[more]

Similar Datasets

| S-EPMC7113885 | biostudies-literature
| S-EPMC5923478 | biostudies-literature
| S-EPMC5997637 | biostudies-literature
| S-EPMC7008383 | biostudies-literature
| S-EPMC5567817 | biostudies-literature
| S-EPMC3144912 | biostudies-literature
| S-EPMC7103675 | biostudies-literature
| S-EPMC9810120 | biostudies-literature
| S-EPMC8610013 | biostudies-literature
| S-EPMC4600983 | biostudies-other