Sequence and structure of human rhinoviruses reveal the basis of receptor discrimination.
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ABSTRACT:
SUBMITTER: Vlasak M
PROVIDER: S-EPMC156168 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Publications
Sequence and structure of human rhinoviruses reveal the basis of receptor discrimination.
Vlasak Marketa M Blomqvist Soile S Hovi Tapani T Hewat Elizabeth E Blaas Dieter D
Journal of virology 20030601 12
The sequences of the capsid protein VP1 of all minor receptor group human rhinoviruses were determined. A phylogenetic analysis revealed that minor group HRVs were not more related to each other than to the nine major group HRVs whose sequences are known. Examination of the surface exposed amino acid residues of HRV1A and HRV2, whose X-ray structures are available, and that of three-dimensional models computed for the remaining eight minor group HRVs indicated a pattern of positively charged res ...[more]
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